Methylmalonyl-CoA mutase uses the 5′-deoxy-adenosylcobalamin form of the cofactor and catalyzes the 1,2 rearrangement of methylmalonyl-CoA to succinyl-CoA. Two chaperones, …

Methylmalonyl-CoA mutase (EC 5.4.99.2, MCM), mitochondrial, also known as methylmalonyl-CoA isomerase, is a protein that in humans is encoded by the MUT gene. This vitamin B 12 …

Among them, methylmalonyl-CoA mutase (MCM) has been extensively studied. This enzyme catalyzes the reversible isomerization of L -methylmalonyl-CoA to succinyl-CoA using …

Sep 1, 1992 · Mechanism of Action of Vitamin B12. Ultrafast Radical Clocks Provide No Evidence for Radical Intermediates in Cyclopropane Models for the Methylmalonyl-CoA to Succinyl-CoA …

methylmalonyl-CoA mutase Co+3 is the “resting” oxidation ! state of the B 12 coenzyme; during! catalysis, Co+3 is converted! to the Co+2 oxidation state.!

One of them suggested by WHITLOCK (5) involves a methylmalonyl group transfer from coenzyme A to the cobalt atom of coenzyme B12. In order to test this possibility we ran the …

Nonenzymatic Model Reaction for the Coenzyme B 12 -Catalyzed Rearrangement of Methylmalonyl-CoA into Succinyl-CoA. Angewandte Chemie International Edition in English …

MCM catalyzes the interconversion of (R)-methylmalonyl-CoA and succinyl-CoA, a bidirectional reaction used in propionate metabolism (12,75,76), catabolism of branched amino acids and...

B12-dependent methylmalonyl-CoA mutase catalyses the interchange of a hydrogen atom and the carbonyl-CoA group on adjacent carbons of methylmalonyl-CoA to give the rearranged …

A nonenzymic model for the coenzyme B12-dependent isomerization of methylmalonyl-SCoA to suiccinyl-SCoA. Tetrahedron 1984 , 40 (16) , 3063-3067. https://doi.org/10.1016/S0040 …