Researchers at the University of Oxford and Nanyang Technological University, Singapore (NTU Singapore) have uncovered the ...

Researchers at the University of Oxford and Nanyang Technological University, Singapore (NTU Singapore) have uncovered the mechanism by which cells identify and repair a highly toxic form of DNA ...

Researchers at the University of Oxford and Nanyang Technological University, Singapore (NTU Singapore) have uncovered the ...

Researchers at the University of Oxford and Nanyang Technological University, Singapore (NTU Singapore) have uncovered the ...

A new "toolkit" to repair damaged DNA that can lead to aging, cancer and motor neuron disease (MND) has been discovered by scientists at the Universities of Sheffield and Oxford.

The major product of DNA-methylating agents, N7-methyl-2′-deoxyguanosine (MdG), is a persistent lesion in vivo, but it is not believed to have a large direct physiological impact. However, MdG reacts ...

Similarly, SPRTN/Wss1 interacts specifically with p97/Cdc48 bound to UFD1‐NPL4 (Davis et al, 2012). These data raise the possibility that Ubx5 acts in DPC repair specifically along with ...

DNA-protein cross-links (DPCs) are generated by internal factors such as cellular aldehydes that are generated during normal metabolism and external factors such as environmental mutagens. A ...

Thus, SPRTN promotes repair of unmodified, ubiquitinated, and SUMOylated DPCs. Interestingly, evidence suggests that proteasome and SPRTN-mediated DPC degradation are non-redundant pathways, as ...

Replication-coupled DPC repair involves DPC degradation by proteases such as SPRTN or the proteasome and the subsequent removal of DNA-peptide adducts by nucleases and canonical DNA repair pathways.