Pregame analysis and predictions of the Kansas City Royals vs. Chicago Cubs MLB game to be played on July 21, 2025 on ESPN.

Baltimore (Sugano 7-5) at Cleveland (Bibee 5-9), 6:40 p.m. Detroit (Flaherty 5-9) at Pittsburgh (Skenes 4-8), 6:40 p.m. Boston (Buehler 6-6) at Philadelphia (Wheeler 9-3), 6:45 p.m.