c-di-AMP: A cyclic dinucleotide that acts as a second messenger in bacteria, regulating processes such as osmoregulation, cell wall synthesis and stress response.

The group figured out how to control highly reactive cyclic allenes and put them to work building the core of lissodendoric acid A (shown below), an alkaloid compound that might be useful as a ...

Synthesis of c-di-AMP in L. monocytogenes is catalyzed by the diadenylate cyclase DacA, and multidrug resistance transporters are necessary for secretion. To identify additional bacterial factors ...