Pediatric Research - Toll-like receptors, the NLRP3 inflammasome, ... the mechanisms by which this single-nucleotide polymorphism, rs10754558, affects NLRP3 function are unknown.

The paper reports a new version of the Cardean CRISPR-Chip called SNP-Chip that can rapidly detect and quantify single nucleotide polymorphisms (SNPs), or point mutations, in unamplified, genomic ...

Schroder, one of the world’s leading experts in inflammasome biology, has studied NLRP3 for over a decade, and today she directs a center at the University of Queensland dedicated to inflammasomes.

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease. Nature Medicine , 2015; DOI: 10.1038/nm.3804 Cite This Page : ...

The BioAge family of NLRP3 inhibitors has differentiated features including Unique and novel chemical structures and biological properties Drug-like metabolic stability and potent in vivo activity ...