Genome-wide association studies have identified several single-nucleotide polymorphisms (SNPs) linked to colorectal cancer (CRC) risk in European and Asian populations, but studies in admixed ...

Oral, brain-penetrant NLRP3 inflammasome inhibitor being investigated as monotherapy in 24-week Phase 2 RESOLVE-1 trial in 160 patients with obesity, with and without type 2 diabetes ...

BioAge identified NLRP3 as a therapeutic target based on analysis of human aging cohorts by the Company’s platform, which revealed that reduced NLRP3 activity is associated with greater longevity.

High-performance prediction of prostate cancer metastasis based on single nucleotide variations remains a challenge. Therefore, we developed a novel biologically informed deep learning framework, ...

Transcription factors (TFs) are the major components of human gene regulation. In particular, they bind onto specific DNA sequences and regulate neighborhood genes in different tissues at different ...

NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression. Immunity, 2025; DOI: 10.1016/j.immuni.2025.01.007 ...

Background: Immune checkpoint inhibitors (ICIs) have dramatically improved outcomes of patients (pts) with metastatic renal cell carcinoma (mRCC). Unfortunately, adverse events (AEs) can limit ...

Our six-SNP-based classifier could be a practical and reliable predictor that can complement the existing staging system for prediction of localised renal cell carcinoma recurrence after surgery, ...

A three-times-daily, 100 mg/kg oral dose of NT-0796 reduced the body weight of mice with diet-induced obesity by 19% by day 28, according to the journal article. The same dosing regimen of 100 mg ...

Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1) is a pivotal player in m6A recognition, RNA metabolism, and antiviral responses. In the context of cancer, overexpression of hnRNPA2/B1, ...

Nodthera Ltd. claims to be first to demonstrate it is possible to modulate the NLRP3 inflammasome in the brain, after showing there were reductions in inflammatory and disease-specific biomarkers in ...