Thirty-three states, the District of Columbia, and Puerto Rico will participate in CMS’ voluntary Cell and Gene Therapy (CGT) ...

Sickle cell disease can lead to a severe complication known as acute chest syndrome (ACS), but the underlying mechanisms are ...

Intranasal fentanyl is a feasible, safe, and effective option for managing acute pain episodes in adults with sickle cell ...

Discover the current pipeline candidates advancing through the clinic for the treatment of sickle cell disease.

Sickle cell disease can lead to a severe complication known as acute chest syndrome (ACS), but the underlying mechanisms are not well understood. A new study by Mass General Brigham investigators ...

The misshapen cells tend to block blood flow in the vessels, leading to frequent pain episodes, infections, and damage to organs.

Pain is the hallmark of sickle cell disease (SCD) and it can be severe, frequent and unpredictable. Although nociceptive pain is more common, at times, people with SCD may have neuropathic pain. The ...

Higher pain scores at the time of discharge from the emergency department (ED) may predict the likelihood of hospitalization in children with sickle cell disease (SCD) who seek emergency care for ...

NIH cancels research grant for disease that affects mostly Black patients, citing DEI, doctor says 90% of Sickle cell disease patients are Black, according to NIH ...

Bottom line We are uncertain which medicines provide the best pain relief for adults experiencing a painful sickle cell crisis. Background People with sickle cell disease have abnormally shaped red ...

Article citations More>> Jacob, E., Chan, V.W., Hodge, C., Zeltzer, L. and Zurakowski, D. (2011) Self-Reported Pain in Children with Sickle Cell Disease: Impact of Age and Disease Severity. The ...

The MC3R, MC4R and MC5R receptors appear to be strategic biological targets in the study of sickle cell pain, due to their shared involvement in inflammatory and nociceptive signaling pathways, their ...