Characterization of intracellular synapse heterogeneity aides to understand the intricate computational logic of neuronal circuits. Despite recent advances in connectomics, the spatial patterns of ...

Rats exhibit significant recovery of locomotor function following incomplete spinal cord injuries, albeit with altered gait expression and reduced speed and stepping frequency. These changes likely ...

How hippocampal place cells and synaptic plasticity contribute to the progressive acquisition of memories by Ingrid Fadelli, Phys.org ...

Synaptic long-term potentiation (LTP) involves generation of myristic acid from synaptic membrane phospholipids via the activity of the phospholipase A1 DDHD2. This work shows that myristic acid ...

Synaptic and intrinsic forms of homeostatic plasticity adjust different aspects of neuronal excitability to preserve circuit excitation–inhibition balance; here, we show that they sense distinct ...

Neurons Use Multiple Plasticity Rules for Learning Behavior UCSD researchers reveal how different parts of neurons follow separate learning rules, changing synaptic connections.

Our research provides a clearer understanding of how synapses are being modified during learning, with potentially important health implications since many diseases in the brain involve some form ...

The proposed memristor-based neural circuit exhibits synaptic plasticity, one of the important neurochemical foundations for learning and memory, which is demonstrated via the efficient imitation of ...

Other rules of synaptic plasticity appear to have a bigger effect and better explain how brain activity continually reshapes the way memories are recorded in the brain.

A study mapped genes linked to schizophrenia and uncovered a mechanism that disrupts synaptic plasticity in affected individuals. The researchers showed the role of three proteins in mediating the ...

Synaptic plasticity – a cellular mechanism whereby the strength of synaptic connections between neurons strengthens or weakens over time – is crucial for learning and memory. Disruptions in this ...

The diagrams have been so successful that it can be hard to remember that our cells are not, in fact, filled with colorful ribbons and broad arrows. The Face of Proteins The pencil smudges on ...