CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

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The RNA Institute, University at Albany, State University of New York, Albany, New York 12222, United States Department of Biological Sciences, University at Albany, State University of New York, ...

The team observed a 4.4-fold increase in the editing efficiency of this modified nuclease, surpassing most of the commonly used RNA-guided endonucleases, including CjCas9. They called this variant ...

The technology relies on the engineered nuclease, also known as “god’s knife,” at a specific location in the genome to produce a site-specific double-stranded break (DSB), induction of organisms ...

CRISPR-Cas9 (clustered regularly interspaced short palindromic repeat and associated Cas9 protein) is a molecular tool with transformative genome editing capabilities. At the molecular level, an ...

Mitochondrial membrane dynamics is a cellular rheostat that relates metabolic function and organelle morphology. Using an in vitro reconstitution system, we describe a mechanism for how mitochondrial ...

Following digestion of the strain preparations with DNase I and S1 nuclease, a complex pattern with six bands from 1.3 to 4.0 kb was observed (Figure 1A). In subsequent experiments, the results of ...