Edited by Karen Young Kreeger J.A. Bennett, R. Dingledine, "Topology profile for a glutamate receptor: Three transmembrane domains and a channel-lining reentrant membrane loop," Neuron, 14:373-84, ...

Pain is easy to understand until it isn’t. A stubbed toe or sprained ankle hurts, but it makes sense because the cause is ...

Imagine your immune cells could be modified to attack any kind of cancer. T cell receptor (TCR) therapy has the potential to ...

Receptors are specialised membrane‐bound proteins that play a fundamental role in translating extracellular signals into precise intracellular responses. Integral to cellular communication ...

Although scientists can learn a lot from cell culture and animal models, they cannot truly substitute for all parts of the human body, especially the brain. But scientists have now used human brain ...

Pleasant tactile stimulation drives social bonding in many animal species, especially mammals. Tactile stimulation forms the ...

Metabolic hypogonadism, a condition marked by low testosterone levels and frequently seen in obese individuals, contributes ...

Epidermal growth factor receptor (EGFR) signaling inhibition represents a highly promising arena for the application of molecularly targeted cancer therapies. Evolving from several decades of ...

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

ABSTRACT: Androgen receptor (AR) is a member of the steroid hormone receptor family of molecules. AR primarily is responsible for mediating the physiologic effects of androgens by binding to specific ...