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This makes it challenging to identify the rate-limiting step of the overall reaction. As a result, optimizing photocatalytic reactions for maximum efficiency remains a significant challenge.
One concern about introducing nanoparticles into the body is that they have a very high surface area that nucleates protein assembly — the rate-limiting step in the formation of harmful fibrils.
Nature Structural & Molecular Biology - Chain collapse can occur concomitantly with the rate-limiting step in protein folding Skip to main content Thank you for visiting nature.com.