Ap sites are known to stall DNA-dependent RNA polymerases (RNAPs). RNA polymerase II (Pol II) briefly stalls at these sites before slowly bypassing them.

A breakthrough assay is advancing how researchers observe gene expression in real time. Named QRIVTA (quantitative real-time ...

This new review article highlights the critical role of ribosome biogenesis in liver health and disease progression.

This new review article highlights the critical role of ribosome biogenesis in liver health and disease progression. As the center of protein ...

Professor Hirohide Saito (Department of Life Science Frontiers at CiRA / The University of Tokyo) and Assistant Professor ...

Scientists have created an artificial RNA system that can copy itself using simple building blocks and temperature changes.

The researchers found that using a drug to inhibit RNA Polymerase 1 (Pol 1) - the enzyme responsible for human ribosomal RNA (rRNA) transcription - triggered a unique stress response that rewires ...

This important study looks into the effect of exogenous CoA on the response of TLR4-activated macrophages. Specifically, CoA enhances the LPS response by examining metabolomics, 13C tracing, and ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...