Look inside a brain cell with Huntington's disease or ALS and you are likely to find RNA clumped together. These solid-like clusters, thought to be irreversible, can act as sponges that soak up ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

With the firing of a virtual starting gun, theoretical chemists around the world cracked their knuckles, filled their coffee pots, and fired up their high-performance computers. Participants in the ...

Until now, the structure and function of the Nipah virus polymerase remained poorly understood. Unraveling this piece of the viral apparatus is the critical first step toward developing ways to ...

To gain further insights into the mechanism of RNA synthesis, we constructed a composite model by integrating the cryo-EM structure of RdRp-domain and PRNTase-domain, and the crystal structure of ...

This allows them to be inserted into the nascent RNA. Remdesivir (RDV) was developed to fight the Ebola virus back in 2014 but was repurposed against the current coronavirus disease 2019 (COVID-19).

Antiviral drug therapy against SARS-CoV-2 is not yet established and posing a serious global health issue. Remdesivir is the first antiviral compound approved by the US FDA for the SARS-CoV-2 ...

A team in China led by Zihe Rao at Tsinghua University report the cryo-electron microscopy (cryo-EM) structure of the RNA-dependent RNA polymerase (RdRp), which is a key part of the virus’s ...

To find out how the viral RNA polymerase works, the researchers also determined its three-dimensional structure during different transcription steps. With these new findings, it is now possible to ...

Intrinsic cleavage of RNA polymerase II adopts a nucleobase-independent mechanism assisted by transcript phosphate. Nature Catalysis, 2019; 2 (3): 228 DOI: 10.1038/s41929-019-0227-5 ...

Senior and Reviewing Editor; University of California, Berkeley, United States In the interests of transparency, eLife includes the editorial decision letter and accompanying author responses. A ...

Abstract Most double-stranded RNA (dsRNA) viruses transcribe RNA plus strands within a common innermost capsid shell. This process requires coordinated efforts by RNA-dependent RNA polymerase (RdRp) ...