DNA makes RNA, RNA makes protein, protein makes phenotype—was the guiding framework for understanding inheritance and disease ...

A significant percentage of patients with SSc first present with non-RP symptoms — most commonly puffy fingers/hands — and are associated with more severe disease.

Billions of years ago, a rock crack exuding heat could have brought different biomolecules together to kickstart protein ...

Maintaining high transcriptional fidelity is essential to life. For all eukaryotic organisms, RNA polymerase II (Pol II) is responsible for messenger RNA synthesis from the DNA template. Three key ...

A new study reveals that blocking ribosomal RNA production rewires cancer cell behavior and could help treat genetically ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

Each 100 μl reaction contained 2.5 U of Pfu Turbo polymerase (Stratagene), 1× cloned Pfu buffer (10 mM (NH 4) 2 SO 4, 20 mM Tris pH 8.8, 2 mM MgSO 4, 10 mM KCl, 0.1% Triton X-100, and 0.1 mg ml ...

Researchers at the Johns Hopkins Kimmel Cancer Center and Department of Radiation Oncology and Molecular Radiation Sciences uncovered a new tumor-suppressive response that could lead to novel ...

The researchers found that using a drug to inhibit RNA Polymerase 1 (Pol 1) - the enzyme responsible for human ribosomal RNA (rRNA) transcription - triggered a unique stress response that rewires ...

Laiho holds patents on RNA polymerase 1 inhibitors, which are managed by The Johns Hopkins University in accordance with its conflict-of-interest policies.