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One of the most important advantages of this test, called ALFA (Aptamer-based Lateral Flow Assay), is that it costs less than one euro, making it a viable option for use in public health programs ...

By combining the aptamer with a nanoparticle ... Aptamers are DNA or RNA strands that adopt a specific three-dimensional structure, allowing them to bind with high affinity to target molecules.

Get Instant Summarized Text (Gist) A computational tool named NuFold has been developed to model 3D RNA structures, potentially accelerating medical discoveries by decades. This tool addresses the ...

Biologists have discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA transcripts. RNA splicing is a cellular ...

Read the paper: Tumour-wide RNA splicing aberrations generate actionable public neoantigens Cancer cells harbour gene mutations that are absent in normal cells, allowing the immune system to ...

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...

Faculty of Materials Science and Engineering, Hubei Polytechnic University, Huangshi 435003, Hubei, P. R. China State Key Laboratory of Geomicrobiology and Environmental Changes, Engineering Research ...

Aptamers are short, single-stranded DNA or RNA oligonucleotide sequences that can bind specific ... could greatly increase the proportion of aptamer moiety. However, some LMWCAs could bind to other ...

Given the challenges in modeling complex RNA dynamics, our work demonstrates that MD simulation with a polarizable force field is valuable for understanding aptamer-fluorogen binding and potentially ...

Internal ribosome entry sites (IRESs) are important RNA-based translation initiation signals, critical for infection by many pathogenic viruses. The hepatitis C virus (HCV) IRES is the prototype for ...