Further experiments confirmed that immunoprecipitated pyruvate dehydrogenase complex subunit E2 showed reduced levels of lipoylation in ECHS1 KO cells, which were again normalized in double KO cells ...

Just before she turned one, Harlow was diagnosed with Pyruvate Dehydrogenase Complex Deficiency, commonly called PDCD.

Biochemists discover self-repair function in key photosynthetic protein complex by Steve Koppes, Purdue University Editors' notes ...

The FDA has accepted for Priority Review the NDA for SL1009 to treat pyruvate dehydrogenase complex deficiency.

DCA will be used with a proprietary genetic test to treat an orphan pediatric mitochondrial disease, Pyruvate Dehydrogenase Complex Deficiency (PDCD) 1. The FDA granted Priority Review for the NDA and ...

If approved, SL1009 has the potential to be the first approved medication for PDCD, and would be available as an oral solution. A New Drug Application SL1009, Sodium Dichloroacetate Oral Solution (DCA ...

Scientists at Université de Montréal and its affiliated Montreal Clinical Research Institute (IRCM) have uncovered unique roles for a protein complex in the structural organization and function ...

Pyruvate dehydrogenase complex (PDC) deficiency is a major cause of primary lactic acidemia resulting in high morbidity and mortality, with limited therapeutic options. The E1 component of the ...

The pyruvate dehydrogenase complex (PDC) generates acetyl-CoA from pyruvate, and is recently shown to translocate from the mitochondrial matrix into the nuclear under mitogenic and stress conditions ...

This paper reports the discovery that the activity of the multienzyme pyruvate dehydrogenase complex from beef kidney mitochondria is regulated by a phosphorylation-dephosphorylation reaction sequence ...

Saol Therapeutics announced that the pivotal Phase 3 clinical trial evaluating Sodium Dichloroacetate for the treatment of a rare, pediatric, ultra-orphan mitochondrial disease, Pyruvate Dehydrogenase ...