Individual enzymes frequently form a complex with many subunits, as in the case of the pyruvate dehydrogenase complex. It occurs in all human, animal, and plant cells, as well as in fungi and even ...

PYRUVATE DEHYDROGENASE COMPLEX . Indications: Pyruvate dehydrogenase complex deficiency, typically associated with post-prandial lactic acidemia with a normal lactate/pyruvate ratio, can be assayed in ...

The NDA is supported by data from a double-blind, crossover phase 3 study evaluating SL1009 in young children with a confirmed pathological mutation in the pyruvate dehydrogenase complex.

The pyruvate dehydrogenase complex reaction is allosterically inhibited when there are high ratios of ATP to ADP, NADH to NAD + and acetyl-CoA to CoA. Allosteric activation occurs when the ratio ...

Saol Therapeutics, a privately held, clinical-stage pharmaceutical company, announced today that the U.S. Food and Drug Administration (FDA) has accepted for review the New Drug Application (NDA ...

Saol Therapeutics, a privately held, clinical-stage pharmaceutical company, announced today that the U.S. Food and Drug Administration (FDA) has accepted for review the New Drug Application (NDA) for ...