These cells conceal integrated provirus in a transcriptionally silent state, beyond the reach of both immune surveillance and antiretroviral therapy. Researchers at the Peter Doherty Institute in ...

The HIV provirus is subject to several host transcriptional blocks that prevent its reactivation, including blocks preventing transcription initiation and/or ending transcriptional elongation before a ...

Human T-cell lymphotropic virus type-1 (HTLV-1) has a large global burden and in some key communities, such as Indigenous Australians living in remote areas, greater than 45% of people are infected.

An immune response that likely evolved to help fight infections appears to be the mechanism that drives human immunodeficiency virus (HIV) into a latent state, lurking in cells only to erupt anew ...

The virus persists by integrating its genetic material – or "provirus" – into their genome. This makes it undetectable to the immune system, but also inaccessible to antiretroviral drugs.

The first in-human trial of a CRISPR Cas system delivered by adeno-associated virus 9 gene therapy to treat HIV was able to target only the intended DNA and cleared the blood within 6 months.

From my understanding, genomad is recommended as a more accurate tool for provirus detection. I'm wondering if I should treat the 870 provirus predicted by checkv just as "regular" viruses and trust ...

A mutation that can undermine two-drug treatment with dolutegravir and lamivudine persists for at least 12 years in the ‘archive’ of HIV locked up in the DNA of blood cells in one in three people ...

By synchronizing the emission spectrum change of the fluorescent timer protein with provirus expression, HIV-Tocky enables precise tracking of provirus temporal dynamics from expression to silence.

The human ERV-K exists in the provirus form in the human genome, comprising sequences encoding proteins critical for the reactivation, and RVLP (retrovirus-like particle) formation, having ...

CentralStar Cooperative’s research and development team developed an assay (the SS1 qPCR assay) that can accurately quantify the concentration of provirus circulating in an individual animal, ...

Viruses insert their genomes into their hosts in the form of a provirus.