Insights into the structures could lead to improved treatment strategies for transthyretin amyloidosis, a progressive, fatal disease in men.

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

Ligand Pharmaceuticals Incorporated, a biopharmaceutical company, engages in the development and licensing of biopharmaceutical assets worldwide. Its commercial programs include Kyprolis and ...

The best protein shakers are a must-buy, so we've tried and tested the best on the market to help you decide what to carry before, during and after your workouts. And we've done that much testing ...

A novel geometric deep learning framework designs ligand-specific protein binders, enhancing therapeutic potential in cell therapies and synthetic biology.

In biology, the binding of cellular proteins to molecules called ligands produces a myriad of functions essential for life, including cell signaling and enzymatic action. In biotechnology and medicine ...

Conclusion: Unlike conventional structure-based or ligand-based screening methods, this work emphasizes the role of specific protein conformations in driving ligand binding, making the process highly ...

"These findings open new possibilities for protein-ligand complex modeling, indicating significant potential for ProteinReDiff in various biotechnological and pharmaceutical applications." ...

The ability to alter protein binding can create tailored therapeutics with reduced side effects, sensitive diagnostic tools, targeted drug delivery and sustainable bioremediation. Various approaches ...

Vivek Vishnudas discusses the unique advantages of E2-based TPD and its potential to revolutionize treatment for challenging diseases.

but we wanted to design a novel protein that would bind to a defined protein-drug complex," says LPDI scientist and co-first author Anthony Marchand. Remarkably, the team showed that MaSIF could ...