Fit-ligand is a computational algorithm that enables accurate modeling of multiple conformational states of ligands in X-ray crystallography and cryo-electron microscopy (cryo-EM).

Advancements in artificial intelligence (AI) are dramatically transforming the field of protein science, offering powerful ...

Here we use cryogenic electron microscopy to determine the structure of TbAQP2 from Trypanosoma brucei, bound to either the substrate glycerol or to the sleeping sickness drugs, pentamidine or ...

CORD: A Comprehensive Portal into Chordate Olfactory Receptors. GA, UNITED STATES, June 30, 2025 /EINPresswire.com/ -- How animals sense and respond to smells plays a pivotal role in their survival, ...

Here, a genetic-engineering-free method to modify receptor proteins with various probes in the live mouse brain is reported by combining ligand-directed chemistry with click chemistry.

Imagine a world without disease. Sounds utopian? AI just made it a multibillion-dollar bet to discover drugs – and forget Big ...

Third, complex proteins consisting of several polypeptide chains or requiring certain post-translational modifications may be intrinsically incompatible with display on phage, bacteria, or yeast.

Immune checkpoint inhibitors (ICIs) are a type of immunotherapy or cancer treatment that targets specific immune cells known ...

A mixed bag of top-line phase II data prompted stellar stock results for Prokidney Corp. and its chronic kidney disease (CKD) and diabetes therapy, rilparencel. There were statistically significant ...

After years of development, Isomorphic Labs says its AI-created drugs are nearly ready for human trials. Isomorphic Labs, the ...

European Commission Approves Biocon Biologics’ Denosumab BiosimilarsBengaluru, Karnataka, India, July 3, 2025 Biocon Biologics Ltd (BBL), a fully integrated global biosimilars company and subsidiary ...