A team led by UT Southwestern Medical Center researchers has uncovered the atomic structure of a protein complex pivotal to ...

The natural protein universe is vast, and yet, going beyond and designing new proteins not observed in nature can yield new ...

Large-scale redesigns, including changes to core domains, may retain stability—challenging assumptions that such regions are off-limits.

For most proteins, structure is function. The complex three-dimensional shapes that proteins adopt create folds and pockets that can accomplish the remarkably improbable: driving chemical ...

Inside each cell of the human body are proteins that control which genes are expressed at the right place and time. However, ...

Intrinsically unstructured proteins: Re-assessing the protein structure-function paradigm. J Mol Biol. 1999;293(2):321-331. Lindorff-Larsen K, et al. Determination of an ensemble of structures ...

Premier food research lab addresses widespread protein deficiency in India, focusing on alternative protein sources at national symposium.

“Our results provide an explanation and illustration of how kinetics can also control protein structure and function,” said Ed O’Brien, PhD, a professor of chemistry at Penn State, and the ...

In a new study, Nobel laureate David Baker and colleagues detail new methods for targeting undruggable "disordered" proteins.

For the first of these tasks Dr Baker and his colleagues use RF diffusion, an AI model they have developed to predict a ...