A team led by UT Southwestern Medical Center researchers has uncovered the atomic structure of a protein complex pivotal to ...

The natural protein universe is vast, and yet, going beyond and designing new proteins not observed in nature can yield new ...

Inside each cell of the human body are proteins that control which genes are expressed at the right place and time. However, ...

For most proteins, structure is function. The complex three-dimensional shapes that proteins adopt create folds and pockets that can accomplish the remarkably improbable: driving chemical ...

Protein gives you energy thanks to amino acids. Learn why researchers want to reassess daily protein recommendations and what ...

Intrinsically unstructured proteins: Re-assessing the protein structure-function paradigm. J Mol Biol. 1999;293(2):321-331. Lindorff-Larsen K, et al. Determination of an ensemble of structures ...

“Our results provide an explanation and illustration of how kinetics can also control protein structure and function,” said Ed O’Brien, PhD, a professor of chemistry at Penn State, and the ...

In a new study, Nobel laureate David Baker and colleagues detail new methods for targeting undruggable "disordered" proteins.

Semirational protein design is a combination of rational and directed evolution methods. 9 Scientists consider this strategy more effective because they can use computational or bioinformatic modeling ...

For the first of these tasks Dr Baker and his colleagues use RF diffusion, an AI model they have developed to predict a ...