Researchers at the University of Basel have repurposed a natural enzyme so that it catalyzes a highly challenging chemical ...

Our findings indicate an impaired function of the PDH enzyme complex, resulting in reduced flux of pyruvate to the [tricarboxylic acid (TCA)] cycle.

These enzymes are known as the alpha-ketoglutarate complex (KGDH) and the pyruvate dehydrogenase complex (PDH). Previously, the researchers showed that CPI-613 attacked PDH by activation of ...