eLife2d
Synthetic gene circuits that selectively target RAS-driven cancers
This important study demonstrates the potential of synthetic gene circuits to detect and target aberrant RAS activity in cancer cell lines. The circuit design is novel and the evidence supporting the ...
eLife4d
Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche
Megakaryocytes form a three-dimensional (3D) cage composed of laminin and collagen IV connected to the basement membrane surrounding them. This microarchitecture stabilizes megakaryocytes within their ...
ALZFORUM1d
Expanded Repeat Sequences Raise a Person’s Risk for Alzheimer’s
Repeats Raise Risk. The more STR expansions a person carried, the higher their odds for AD (left). People with more repeat expansions tended to have worse tau pathology as per Braak stage (right).
25 Facts You Learned in School That Are No Longer True
Prepare to get schooled If you have kids in school, or even if you don’t, you’ve probably realized that there’s a lot about ...
Inside Walton Goggins’s Enchanting 1920s New York Lodge
AD is welcomed by actor Walton Goggins to tour his home in Hudson Valley, New York. When ‘The White Lotus’ star and his wife ...
Nature4d
Mitochondrial control of cell death
Figure 1: Mitochondrial involvement in cell death. Mitochondria are organelles with two well-defined compartments: the matrix, surrounded by the inner membrane (IM), and the intermembrane space ...