Here, the crystal structure of the complex between RCC1 and the nucleosome core particle provides an atomic view of how a chromatin protein interacts with the histone and DNA components of the ...

DNA lesions are repaired by a cut-and-remove process called nucleotide excision repair. An in vitro biochemically defined system has been developed in which six repair factors are sufficient to excise ...

Chinese scientists reported the first high-resolution cryo-EM structure of human Polycomb repressive deubiquitinase (PR-DUB) complex bound to the chromatosome particle with mono-ubiquitinated ...

A group including Jonathan Widom at Northwestern University and Eran Segal of the Weizman Institute used sophisticated computer modeling along with experimental approaches to uncover DNA-encoded rules ...

An intermediate chromatin structure during nucleosome remodeling is determined, and may explain how nucleosome repositioning occurs Peer-Reviewed Publication Waseda University ...

Scientists have long known that cells in all eukaryotes, from fish to trees to people, pack DNA in exactly the same way. DNA strands are wound around a ‘hockey puck’ composed of eight histone proteins ...