Locked nucleic acid (LNA) probes are modified RNA bases where the ribose is locked, thus fixing a specific conformation. They enable shorter probes for qPCR, thereby improving assay sensitivity ...

Fluorescent probes have emerged as indispensable tools in the detection and imaging of nucleic acids, underscoring advances in both fundamental research and clinical diagnostics.

Luo, J.D. et al. Detection of rare mutant K-ras DNA in a single-tube reaction using peptide nucleic acid as both PCR clamp and sensor probe. Nucleic Acids Res. 34 , e12 (2006). Article Google Scholar ...

Five years ago, the NCBI Probe database (ProbeDB) was established to provide a centralized archive of molecular probes used in biomedical applications. Currently ProbeDB contains around 10 million ...

Nucleic acids may be labeled at their 3’ end, 5’ end, ... it is desirable to generate highly specific probes where the label is distributed throughout the nucleic acid.

Triplex-Forming Peptide Nucleic Acid Probe Having Thiazole Orange as a Base Surrogate for Fluorescence Sensing of Double-stranded RNA. Journal of the American Chemical Society , 2016; 138 (30 ...

SIDEBAR: Selected Suppliers of DNA and RNA Probes In the doctor's office or the research lab, the supreme value of DNA and RNA as diagnostic tools and the high potential of genetic therapy are putting ...

First, a peptide nucleic acid (PNA) probe locally opens a chosen target site, which allows a padlock DNA probe to access the site and become ligated. Second, rolling circle amplification ...

NEW YORK--(BUSINESS WIRE)--Enzo Biochem, Inc. (NYSE:ENZ), an integrated diagnostics and therapeutics company, today announced the issuance of U.S. Patent No. 10,323,272 entitled Nucleic Acid ...

The use of nucleic acid amplification tests of “minipools” of 16 samples to screen blood donors for West Nile virus RNA began in July 2003. We report the yield and characteristics of positive ...

Rice University researchers developed a tunable technique to find and quantify DNA and RNA biomarkers ...