Scientists have discovered novel drug candidates that could ultimately lead to new effective treatments for conditions caused ...

Parasympathetic nerve development is, at least in part, dependent on GDNF signaling. Hiltunen et al 48 demonstrated that signaling activity by GDNF family members and their receptors GFRα2 and Ret is ...

Scientists have discovered novel drug candidates which could ultimately lead to new effective treatments for conditions ...

Nicotinic receptors — a family of ligand-gated ion channels that mediate the effects of the neurotransmitter acetylcholine — are among the most well understood allosteric membrane proteins ...

Nicotinic acetylcholine (ACh) receptors and other Cys-loop receptors challenge our ability to understand how proteins carry out simple sets of functions — in this case, specific binding ...

Diets rich in phosphate additives, commonly found in processed foods, can increase blood pressure by triggering a brain ...

FDA raised safety concerns for Vyvgart Hytrulo in CIDP, while Argenx moves ARGX-119 into late-stage trials for rare ...

Afferent signals are sent from a nerve receptor into the brain while efferent signals are sent from the brain to the peripheral body.

ATP-binding cassette (ABC) proteins are highly conserved and widely expressed throughout nature and found in all organisms, both prokaryotic and eukaryotic. They mediate myriad critical cellular ...

Objective: The capsaicin receptor TRPV1 (transient receptor potential vanilloid type-1) may play an important role in visceral pain and hypersensitivity states. In irritable bowel syndrome (IBS), ...

Chronic pain affects millions of people in the US. Targeting an oft-overlooked brain receptor could one day offer relief.

To test their theory, the researchers first confirmed that both human and mouse endometriosis lesions contain nerve fibers with both CGRP and its receptor, RAMP1. Then, using a mouse model that mimics ...