The mechanisms governing natural killer cell development are not well understood. Activation of the tyrosine kinase receptors Tyro3, Axl and Mer on pre–natural killer cells by stromal cell ...

Newly discovered mechanism of T-cell control can interfere with cancer immunotherapies Date: May 3, 2024 Source: German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) Summary ...

This study revealed the key mechanism of NK cells dysfunction and immune evasion from the perspective of membrane topology, providing a new strategy for NK cell-based tumor immunotherapy.

Receptor engineering has significantly advanced NK cell-based cancer immunotherapies. As technical hurdles are overcome, ...

While studying breast cancer cell lines, Dr. Clément Thomas' research team at the Luxembourg Institute of Health (LIH) uncovered a previously unknown mechanism that leaves tumor cells unharmed by ...

Every NK cell has two types of surface receptors - activators, which turn the killing mechanism 'on' and inhibitors which turn the killing mechanism 'off'.

Senti Bio Releases Mechanism of Action Video for First-in-Class Off-the-Shelf Logic Gated Selective CD33 OR FLT3 NOT EMCN CAR NK Cell Therapy, SENTI-202 ...

Review synthesizes research on NK cells' role in cancer immunity and their potential in therapeutics through bioengineering, immune checkpoint inhibitors, and cell engagers, highlighting ongoing ...

Every NK cell has two types of surface receptors - activators, which turn the killing mechanism 'on' and inhibitors which turn the killing mechanism 'off'.

When screening activated T cells from healthy donors, Platten's team identified the protein B7H6 as a recognition molecule for NK cell attacks in a new study.

More information: Michael Kilian et al, The immunoglobulin superfamily ligand B7H6 subjects T cell responses to NK cell surveillance, Science Immunology (2024).