The increased putative functional synapses in the dentate gyrus is likely related to the increased adult neurogenesis observed in the Down syndrome mice following GENUS treatment." ...

Interleukin-1 (IL-1) is a key molecule involved in inflammation and plays an important role in both healthy and diseased ...

Vector administration in the dentate gyrus allows for efficient and nearly selective in vivo overexpression of NPY and Y2 receptor in granule cell mossy fiber terminals.

Circuit-based intervention corrects irreconcilable excitability defects between dentate granule cells and mossy cells in Fmr1 knockout mice, representing a promising strategy to restore the dentate ...

Synopsis A pool of adult neural stem cells in the dentate gyrus of the hippocampus supports lifelong neurogenesis, but its origins are unclear. This pool is shown here to be established in mice ...

Neurogenesis continues during adulthood in two brain neurogenic niches, the dentate gyrus of the hippocampus and the subventricular zone (SVZ) adjacent to lateral ventricles. In these areas new ...

A team of researchers affiliated with several institutions in the U.S. reports that newly generated nerve cells in the brain's dentate gyrus impact older nerve cells in two ways. In their paper ...

Figure 1. Definitions of the dentate gyrus layers. Illustrations represent a complete sample of every 12th section of a horizontal series passing through the mouse dentate gyrus from dorsal to ventral ...