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Beyond the crystal: Dynamic model captures loop flexibility in swine virus drug design
Porcine reproductive and respiratory syndrome virus (PRRSV) continues to devastate the global swine industry, yet the ...
Research teases apart competing transcription organization models
Scientists at St. Jude Children's Research Hospital have reconciled two closely related but contentious mechanisms underlying ...
High-velocity molecular clouds in M83 provide new insight into how galaxies evolve
A new result from the molecular gas survey in the Southern Pinwheel Galaxy M83 using the Atacama Large ...
C&EN4d
Multiple Pharmacophore Models Combined with Molecular Docking: A Reliable Way for Efficiently Identifying Novel PDE4 Inhibitors with High Structural Diversity - ACS Publications
Multiple pharmacophore models were constructed based on the 18 crystal structures of phosphodiesterase 4 (PDE4) in complex with different inhibitors for discovering new potential PDE4 inhibitors.