Enzymes catalyze chemical reactions in organisms - without which life would not be possible. Leveraging AlphaFold2 artificial ...

Markov State Model To complement the analysis of the simulations we use a Markov state model (MSM). (51) This analysis is particularly important in the case of the helix-biased model, since the ...

Finally, the hidden Markov model with expectation maximization is built by exploiting postprocessing temporal optimization. Experimental results show that the proposed method can outperform other ...

Using a novel metric for the cooperativity, we identify those residues leading to the least cooperative folding. The folding dynamics of the selected mutants are then directly characterized and the ...

Traditional static algorithmic models often struggle to effectively capture the dynamic and evolving nature of consumer behavior in multichannel shopping environments, where consumers frequently ...