The “lock and key” model was first proposed in 1894. In this model, an enzyme’s active site is a specific shape, and only the substrate will fit into it, like a lock and key.

In anger, she questions what is wrong with her lock and key. Alfred, the science app, responds by explaining how enzymes work in relation to the ‘lock and key’ model.

Researchers at Washington University School of Medicine in St. Louis have revealed the structure of a key protein involved in ...

In anger, she questions what is wrong with her lock and key. Alfred, the science app, responds by explaining how enzymes work in relation to the ‘lock and key’ model.