Twenty-two percent of children with juvenile localized scleroderma have extracutaneous manifestations, and nearly half of those cases have joint involvement. (Zulian F et al. 2005; 52:2873-2881.) ...

Scleroderma is a rare, autoimmune condition in which the body produces too much collagen, causing the skin and connective tissue to thicken. Medical News Today Health Conditions ...

A parent is concerned because her 9-year-old daughter has been diagnosed with "localized scleroderma," after years of seeing physicians and not getting a diagnosis. A dermatologist told her to do ...

There are two types of scleroderma. Localized scleroderma is confined to the skin on the hand and face while in systemic scleroderma the disease could spread to the internal organs.

If other organs are affected you have systemic scleroderma. With localized disease, your scleroderma symptoms may include: Swelling, stiffness, or pain in the fingers, toes, hands, feet, or face; ...

Long-term methotrexate therapy was a beneficial, well-tolerated treatment for juvenile localized scleroderma, according to study results. Researchers in Italy evaluated 65 patients with juvenile ...

Weibel L et al. (2007) Laser Doppler flowmetry for assessing localized scleroderma in children. Arthritis Rheum 56: 3489–3495 ...