In its most general use, "ligand" is a term for something that binds to a receptor. Often, ligands are made of proteins, like their receptors, and the binding connection between the two will cause ...

Researchers now offer a simplified method they call ProteinReDiff that uses artificial intelligence to speed the redesign of ligand-binding proteins. In biology, the binding of cellular proteins ...

We often think about diseases in terms of the symptoms they present. A cold might give you the sniffles or even GI distress, while malaria can give you fever, chills, or nausea, for example. These ...

Researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel drug ...

Cys-loop receptors are ligand-gated ion channels ... By probing canonical binding sites with a competition ligand-binding assay, Godellas discovered that the linker region does not tolerate ...

Announcing a new publication for Acta Materia Medica journal. Single-cell RNA sequencing (scRNA-seq) data from published datasets were obtained to investigate the expression and dysregulation of ...

Researchers led by Truong Son Hy, Ph.D., from the University of Alabama at Birmingham, offer a simplified method they call ProteinReDiff that uses artificial intelligence to speed the redesign of ...