In its most general use, "ligand" is a term for something that binds to a receptor. Often, ligands are made of proteins, like their receptors, and the binding connection between the two will cause ...

Seth Wander, MD, PhD, discusses the significance of ESR1 mutations in patients with hormone receptor–positive, HER2-negative metastatic breast cancer.

GPR6 is an orphan G protein-coupled receptor primarily expressed in the ... a lipid-like molecule occupying the orthosteric ligand-binding pocket. A cryo-EM structure of the fully active GPR6 ...

PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

Researchers of the study ‘Nanoscale Ligand Spacing Regulates Mechanical Force - Induced Cancer Cell Killing’ explained that cells have surface receptors ... reduces the binding spacing to ...

For example, antibody-drug conjugates use targeted antibodies to deliver highly cytotoxic drugs directly to tumor sites, while receptor ligand peptides armed with MRI agents improve medical imaging.