In its most general use, "ligand" is a term for something that binds to a receptor. Often, ligands are made of proteins, like their receptors, and the binding connection between the two will cause ...

Researchers now offer a simplified method they call ProteinReDiff that uses artificial intelligence to speed the redesign of ligand-binding proteins. In biology, the binding of cellular proteins ...

We often think about diseases in terms of the symptoms they present. A cold might give you the sniffles or even GI distress, while malaria can give you fever, chills, or nausea, for example. These ...

Researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel drug ...

Cys-loop receptors are ligand-gated ion channels ... By probing canonical binding sites with a competition ligand-binding assay, Godellas discovered that the linker region does not tolerate ...

Researchers from Southwest Jiaotong University published the discovery of novel high affinity peptides against the protein of human DNA binding domain of FOXM1 (FOXM1-DBD) to be developed for the ...

Single-cell RNA sequencing (scRNA-seq) data from published datasets were obtained to investigate the expression and ...

Researchers led by Truong Son Hy, Ph.D., from the University of Alabama at Birmingham, offer a simplified method they call ProteinReDiff that uses artificial intelligence to speed the redesign of ...