UC Davis researchers developed JRT, a modified version of LSD that promotes neuroplasticity without hallucinogenic effects. Tested in mice, JRT enhanced brain connectivity, showed antidepressant ...

Finally, new molecular sites and modes of LSD action continue to be uncovered 47. More research is needed to specify risperidone's molecular and cellular mechanisms.

Brain's 'Master Molecule' Produces Same Behavior In Mice From Three Different Psychostimulant Drugs Date: November 24, 2003 Source: Rockefeller University ...

Lysergic acid diethylamide, or LSD, is best known for its powerful mind-altering effects. But in recent years, researchers have discovered that LSD and similar compounds can also promote ...

They used that structure to model the 5HT2a until Roth’s group worked out the crystal structure of 5HT2a. The compounds had been selected from a computational library of 75 million candidates.

In this case, three different drugs of abuse, LSD, PCP ("angel dust") and amphetamine, work on three different neurotransmitters, serotonin, glutamate, and dopamine, respectively.

JRT has the same molecular weight and general shape as LSD. But that small atomic switch made it behave very differently. It became highly selective for the 5-HT2A receptor—the key site for ...

The LSD molecule, in pink, is shown binding to the serotonin 2b receptor. The orange line represents a lidlike protein overhang that keeps the drug bound therein for hours.

An anonymous reader writes: D-lysergic acid diethlyamide…what a strange, wonderous, and downright amazing molecule. Having a background in biology, biochemistry, and molecular biology, I have ...

I initially planned on getting the regular simple stick molecular structure, and sat on that idea for close to 7 years. One night, fairly recently, a tattoo artist friend mentioned to me over lunch ...

Reference: Tuck JR, Dunlap LE, Khatib YA, et al. Molecular design of a therapeutic LSD analogue with reduced hallucinogenic potential. Proc Nat Acad Sci USA . 2025. doi: 10.1073/pnas.2416106122 This ...