In biology textbooks and beyond, the human genome and DNA therein typically are taught in only one dimension. While it can be ...

An international research team has deciphered a mechanism of the evolutionary arms race in human cells. The findings provide ...

Mitochondria are cell organelles surrounded by a double membrane. In addition to numerous essential functions in the ...

DNA makes RNA, RNA makes protein, protein makes phenotype—was the guiding framework for understanding inheritance and disease ...

RNA is emerging as a valuable target for the development of novel therapeutic agents. The rational design of RNA-targeting small molecules, however, has been hampered by the relative lack of methods ...

There are large differences between the intracellular environment and the conditions widely used to study RNA structure and function in vitro. To assess the effects of the crowded cellular environment ...

Further, our single-cell RNA sequencing (scRNA-seq) data revealed that infection with SARS-CoV-2 rewired the gene expression profile of NK, monocytes, CD4 + , CD8 + effector T cells and antibody ...

Modeling the structure and dynamics of large macromolecules remains a critical challenge. Molecular dynamics (MD) simulations are expensive because they model every atom independently, and are ...

BACKGROUND: In this study, we define the mechanistic association between long noncoding RNA: ENST00000495536 (lnc-536) and transcription factor HOXB13 in mediating proproliferative smooth muscle ...

We introduce a melded chemical and computational approach for probing and modeling higher-order intramolecular tertiary interactions in RNA. 2′-Hydroxyl molecular interference (HMX) identifies ...