Borrowing from the anti-inflammatory properties of olive oil, Penn Engineers used a century-old chemical reaction to redesign ...

Many proteins are capable of spontaneously rearranging themselves within cells to form molecular condensates—membraneless ...

As millions of people know firsthand, the most common side effect of mRNA vaccines like the COVID-19 shot is inflammation: ...

In multiple experiments, C-a16 lipids, which contain a phenol group, outperformed LNPs used in currently available mRNA ...

As millions of people know firsthand, the most common side effect of mRNA vaccines like the COVID-19 shot is inflammation: ...

Cells contain helper molecules called transfer RNAs (tRNAs), which carry building blocks (amino acids) to make proteins.

RNA gene scissors (CRISPR-Cas13) are gaining significant attention as a next-generation gene therapy with fewer side effects. They can suppress infection by eliminating viral RNA, such as in ...

Lipid nanoparticles (LNP’s) came to prominence for delivery of RNA with the success of the Moderna and Pfizer BioNTech COVID-19 vaccines. They are also used to deliver therapeutic treatments ...

A mass spec-based method for analyzing the structure of lipid nanoparticles could yield new insights that improve vaccine and drug delivery.

Innovative delivery techniques, including high-tech nanoparticles and electroporationdevices, may convey more gene therapies into the clinic.