A cross-section of an LNP-RNA. The mRNA (red) is encapsulated by lipids (blue spheres with tails). [Yusuke Sato] “Herein, α-branched tail lipids are focused, as they can be synthesized from ...

We hypothesize that the modifications of e-sgRNA facilitate function in part by increasing RNA resistance ... Beyond LNP delivery, we ... H. et al. Crystal structure of Cas9 in complex with guide ...

The results of the study conclude that the AA-T3A-C12 LNP outperforms the MC3 LNP, a clinically utilized non-viral vector that has been FDA-approved for use in hepatic, or liver, cell RNA therapy.

Compared with viral vectors, non-viral delivery vectors are easier to scale up and have the ability to solve the most critical safety issues. Thanks to the LNP-mRNA vaccine that came to the fore ...

For messenger RNA (mRNA) therapeutics and vaccines formulated as lipid nanoparticles (LNPs), the excipients receiving the most attention are the encapsulating lipids. While these compounds are crucial ...