Intervertebral disc degeneration is defined by a progressive loss of water and structure, and consequently of functionality. It differs from the natural aging of the disc by the early onset of ...

Cellular senescence—an irreversible cell-cycle arrest coupled with the production of pro-inflammatory secretions known as ...

Moreover, the cells produced these components in a very similar ratio to that found in an intervertebral disc. The authors concluded that the 10 million cell per mL density presented the best balance ...

Citation: Computational simulator targets intervertebral disk biochemistry to find most common cause of back pain (2025, March 18) ...