This important work offers a fresh perspective central to merozoite surface biology and potential implications on vaccine design, challenging the dogma that MSPs are indispensable invasion engines.

As a negative regulator of innate immune responses and acute T cell-mediated transplant rejection in mice, Siglec-E offers a potential therapeutic target that may be translatable to humans.

By studying the innate immune system, scientists have found connections between the immune systems of bacteria and those of humans. “We only started sequencing large numbers of genomes about 20 years ...

The haematological changes and release of soluble mediators, particularly C-reactive protein (CRP) and nitric oxide (NO), during uncomplicated malaria have not been well studied, especially in ...

Immunity and childhood infection Immune responses are of two broad types – innate and acquired. The innate immune system is the body's first line of defense against pathogens.

Once the parasite matures and is released from the liver into the bloodstream, Plasmodium falciparum displays RH5 and infects red blood cells, which causes disease.

Recently, it became clear that in addition to antibody‐mediated responses, PfEMP1 triggers innate immune responses; however, the role of neutrophils, the most abundant white blood cells in the human ...

The scientists called the process PANoptosis. Investigators also determined that a single innate immune sensor called ZBP1 regulated PANoptosis in flu-infected cells.

Often, once the innate immune system is activated, it alerts the adaptive immune system, triggering a second immune response to enhance activity against invading pathogens.

IgA antibodies are the second-most common antibody family and form a core component of responses in the adaptive immune system, the portion of the immune response dominated by B cells and T cells.

This so-called innate response buys the rest of the immune system time to mount a second, more tailored attack, called the adaptive response, which kicks in about a week later, around the time the ...