Inhibition of histone deacetylases, which has been shown to alleviate renal disease in a mouse model of SLE, does have potential in the treatment of autoimmune rheumatic diseases. 77,78 In line ...

Autoimmune-related skin diseases are a group of disorders with diverse etiology and pathophysiology involved ... The most important epigenetic mechanisms are DNA methylation, histone ...

The histone proteins, in conjunction with the chromatin, constitute the nucleosomes. 1 When the N-terminal tails of histone undergo acetylation or methylation, alterations in chromatin structure ...

The three major features are DNA methylation, histone modifications, ... Specific epigenetic dysregulations in autoimmune diseases may serve as possible disease biomarkers.

Neuroblastoma is a childhood cancer of the sympathetic nervous system, with a propensity for widespread metastasis and aggressive clinical behavior. 1 For patients with so-called high-risk disease ...

The paper 'Histone Deacetylase 7 mediates tissue-specific autoimmunity via control of innate effector function in invariant natural killer T-cells' can be freely accessed online at ...

Many anti-cancer drugs have the unfortunate side-effect of depressing the body’s immune system. So it makes sense that one class of these drugs is being investigated as a way of tackling ...

Methylation of lysine in histone tails, like aberrant DNA methylation, leads to gene silencing and has been linked to cancer. Several KMT writers have been implicated in oncogenesis, including ...