HDAC Inhibitor Clinical Trials and Studies: EMA, PDMA, FDA Approvals, Mechanism of Action, ROA, NDA, IND, and Companies by DelveInsight
DelveInsight’s, “HDAC Inhibitor Pipeline Insight” report provides comprehensive insights about 40+ companies and 50+ pipeline ...
Physician's Weekly18h
Organochlorine Pesticides and Epigenetic Alterations in Brain Cancer.
Epigenetic alterations have emerged as critical factors in the pathogenesis of brain cancer, particularly gliomas. This article explores the impact of organochlorine pesticides (OCPs) on the ...
Rewriting the Rules of Aging: New Chromatin Discovery Challenges Conventional Wisdom
The research could contribute to the development of more effective anti-aging treatments in the future. The body's aging ...
Physician's Weekly3d
Role of Histone Modifications and DNA Methylation in Patients With Psoriasis
The following is a summary of “Histone Modifications and DNA Methylation in Psoriasis: A Cellular Perspective,” published in the January 2025 issue of Allergy and Immunology by Pan et al. Epigenetic ...
Science Daily3d
Uncovering how developmental genes are held in a poised state
New research has investigated the mechanism by which bivalency functions to poise genes for expression during cell differentiation, providing insight into a long-standing paradigm in the regulation of ...
Repressed but ready to go: How bivalency holds developmental genes in a poised state for expression
As well as being essential in the precise packaging of DNA into the space of the nucleus, histone proteins are also the site ...
BioWorld5d
TMP-269 prevents neuronal damage in PD models
Researchers from the University College Cork have described the neuroprotective effect of TMP-269, a class-IIa-specific histone deacetylase (HDAC) inhibitor in preclinical models of PD. Pan-inhibitors ...