Gram-negative bacteria cause the four most frequent types of hospital-acquired infection: pneumonia, intra-abdominal infection, urinary tract infection (UTI), and bloodstream infection.

Small, hydrophilic molecules, including most important antibiotics in clinical use, cross the Gram-negative outer membrane through the water-filled channels provided by porins. We have determined the ...

Methods and analysis This is a multicentre, investigator-initiated, open-label, randomised controlled superiority 1:1 study comparing colistin monotherapy with colistin–meropenem combination therapy ...