A multi-omics study reveals that impaired branched-chain amino acid (BCAA) catabolism is a key driver of sarcopenia, ...

Metabolic alterations in cancer cells are numerous and include aerobic glycolysis, reduced oxidative phosphorylation and the increased generation of biosynthetic intermediates needed for cell ...

Because reactive oxygen species are produced via oxidative phosphorylation during anaerobic glycolysis, via the Schiff reaction during glycation, via glucose autoxidation, and via hexosamine ...

To produce energy, normal cells typically go through a process that starts with glycolysis (the breaking down of glucose, or sugar) and ends with oxidative phosphorylation. In 1931, Otto Heinrich ...

During ischemic conditions, glycolysis replaces oxidative phosphorylation as the primary energy source for brain tissue. However, in the ischemia–reperfusion state, neuronal cells show a particular ...

RNA-seq and MS analyses indicated that L-arginine switched glycolysis to oxidative phosphorylation in inflammatory osteoclasts leading to increased ATP production, purine metabolism and elevated ...

Radiation-induced metabolic changes, including shifts in glycolysis, oxidative phosphorylation, and mitochondrial function, have profound effects on how cancer cells respond to the oxidative stress ...

Loss of SMAD4 induces PGK1 upregulation in PDAC, which enhances glycolysis and aggressive tumour behaviour. Notably, in SMAD4-negative PDAC, nuclear PGK1 preferentially drives cell metastasis via ...

DNA-replication genes were also inhibited (p=0.002), (figure 6B). Gene sets enriched in HAMLET-treated tumours included oxidative phosphorylation (p=0.001) and glycolysis (p=0.013) as well as ...

Endometriosis, a prevalent gynecological condition, is characterized by the growth of endometrial-like tissues outside the ...