The addiction of cancer cells to causal gene fusions often results in amplification, in vivo, which can be exploited to reveal unidentified recurrent gene rearrangements. Based on this observation, we ...

Fusion energy, the process of fusing light atomic nuclei to generate energy, has long been considered the key to a clean and ...

Researchers have found a new gene fusion that is highly expressed in a subset of prostate cancers. This discovery could lead to more accurate prostate cancer testing and new targets for potential ...

Lytgobi is an FGFR inhibitor that received accelerated approval in 2022 to treat adults with previously treated, unresectable ...

Gavreto is recommended as a first-line treatment for metastatic RET fusion-positive, metastatic non-small cell lung cancer, ...

Interestingly, it has been observed that chimeric fusion genes sometimes involve two copies of the same gene (e.g., the alcohol dehydrogenase gene in Drosophila), and when that happens ...

In a comprehensive experimental study, an international team of researchers has confirmed the calculations of a leading ...

TFE3 fusion proteins are the oncogenic drivers of translocation renal cell carcinoma but their mechanism of action remains ...