Homeostatic plasticity, the brain's method of preserving equilibrium in neural circuits, relies heavily on spontaneous ...

Abstract Summary Pharmacological enhancement of endoplasmic reticulum (ER) proteostasis is an attractive strategy to mitigate pathology linked to etiologically-diverse protein misfolding diseases.

CRISPR construct to genetically ablate the GABA transporter GAT3 in the mouse visual cortex, with effects on population-level neuronal activity. This work is important, as it sheds light on how GAT3 ...

Neurosteroids demonstrate significant therapeutic promise through the modulation of the GABA system and warrant further investigation.

A research team at the University of Barcelona's Institute of Neurosciences (UBneuro) has discovered new molecular mechanisms related to the cognitive decline associated with Alzheimer's disease ...

All of the key features of the invention are illustrated by the model to include the wind-wheel, shield and governor mechanism. Diagrams showing the complete design can be found in the patent document ...

[T]his review underscores the substantial therapeutic promise of neurosteroids in mood and neurological disorders. Their modulation of the GABA system emerges as a central mechanism of action ...

Rutile-type GeO2 (r-GeO2) is expected as a next-generation ultra-wide-band-gap oxide semiconductor with controllable p-type and n-type conduction. However, the existence of other polymorphs, such as α ...

Alcohol, benzodiazepines as well as GHB and its precursor drugs all share a similar mechanism of action: they increase GABA activity.

Epilepsy patient samples offer unprecedented insights on brain 'brakes' linked to disorders Date: January 23, 2025 Source: University of California - San Diego Summary: Specific protein receptors ...

Figure 2. Conceptual diagram of compounds bound to the benzodiazepine site of GABAAR as agonists. Full agonists, such as Diazepam or Lorazepam, have a high (* 100%) intrinsic effect on receptors, ...