Gq-coupled neurotransmitter receptors (including muscarinic acetylcholine receptors and metabotropic glutamate receptors) dynamically regulate CGN excitability by inhibition of TASK channels 12,39.

On the intracellular side, the EP1 receptor engaged Gq protein through both conserved and receptor-specific interactions. Residues such as R63 ICL1, E294 6.32, and Q298 6.36 contributed to the ...

Essentially all eukaryotic cells express certain Gq-type G protein-coupled receptors (GPCRs) to mediate responses to hormones, neurotransmitters, sensory stimuli, or cytokines.

Trace amine-associated receptor 1 (TAAR1) is a member of the G protein-coupled receptor (GPCR) TAAR family, which has been shown to be enriched in the central nervous system and periphery. TAAR1 can ...