This important study fills an gap in our knowledge of the evolution of GPCRs in holozoans, as well as the phylogeny of associated signaling pathway components such as G proteins, GRKs, and RIC8 ...

In both cases, the receptor was studied in complex with endogenous mammalian GnRH and the Gq protein. The researchers determined cryo-EM structures for the frog and pig GnRHR–Gq complexes at ...

The researchers used cryo-electron microscopy (cryo-EM) to determine the structure of the human EP1 receptor in complex with PGE2 and the heterotrimeric Gq protein, completing the structural ...