Prostaglandin E2 (PGE2), a bioactive lipid derived from arachidonic acid, mediates a broad range of physiological processes through four G protein-coupled receptor (GPCR) subtypes: EP1–EP4 ...

The researchers used cryo-electron microscopy (cryo-EM) to determine the structure of the human EP1 receptor in complex with PGE2 and the heterotrimeric Gq protein, completing the structural ...

Besides, it was found that GnRH binding triggered conformational changes: the receptor's N-terminus flips outward, and TM6 shifts to form the Gq binding interface.

However, efforts to determine the receptor’s structure have been hampered for decades by its low expression levels and inherent instability, leaving unresolved questions about how GnRH activates ...

G protein-coupled receptors articles from across Nature Portfolio G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand ...

G protein-coupled receptors are embedded in the cell membrane and transmit signals from the outside to the inside of the cell.